Antibacterial Properties of Polymeric Membranes Containing Doxycycline for Potential Applications in Foot Ulcer Treatment
Year: 2025
Type: article
Abstract: Membranes made from biopolymers and loaded with doxycycline were investigated for potential use in the treatment of foot ulcers in diabetic patients. Carboxymethylcellulose (CMC) and chitosan (CHS) membranes were fabricated with 7% glycerol and 1% doxycycline (DOX). Their mechanical and physical properties, biocompatibility, and antimicrobial effects were thoroughly evaluated. The results demonstrated effective antibacterial activity against S. aureus and S. mutans. Based on the mechanical, physical, and hemolytic data, DOX-loaded CMC/CHS/G membranes show promise as a topical wound delivery system.
DOI: 10.3390/ijms26073274
Authors: Stevaly Pérez-Gutiérrez, Jesús Ángel Ramírez-Enciso, Laura Abisai Pazos-Rojas, Abigailt Flores-Ledesma, Eric Reyes-Cervantes, Diana del C. Pazos-Guarneros, Ismael Juárez-Díaz, Paola G. Gordillo-Guerra, Bernardino Isaac Cerda-Cristerna, José Luis Suárez-Franco, Carolina Samano-Valencia, Brenda Erendida Castillo-Silva, Alejandro G Martínez-Guerrero, Gisela N. Rubin de Celis-Quintana, Alberto V. Jerezano-Domínguez
Language: English
Topic: Wound Healing and Treatments
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,499
Award: G3202206113
OpenAlex ID: W4409068269