Work

Development of solid drug nanoparticle dispersions for pulmonary delivery of niclosamide and nitazoxanide via vibrating mesh nebulisation

Year: 2025

Type: article

Abstract: Repurposing very poorly soluble drug compounds for new administration routes is highly challenging; however, we present nebulisable aqueous drug particle dispersions of two agents with appreciable anti SARS-CoV-2 activity for pulmonary delivery.

Source: RSC Pharmaceutics

DOI: 10.1039/d5pm00006h

Authors: Catherine Unsworth, Andrew B. Dwyer, Alison C. Savage, James J. Hobson, Jonathan Massam, Tom O. McDonald, Paul Curley, Andrew Owen, Andrew O'Sullivan, Ronan MacLoughlin, Steve P. Rannard

Institutions: University of Liverpool, Centre of Excellence for Long-acting Therapeutics, Aerogen (Ireland)

Language: English

Topic: Inhalation and Respiratory Drug Delivery

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: UK Research and Innovation, Engineering and Physical Sciences Research Council

Awards: G29644370, New Branched Polymers Excipients and Emulsions for Enhanced Drug Delivery

OpenAlex ID: W4409069372

FWCI: 0.608

Cites: 68

Cited by: 1

Related to: 10