Work

Aortic endograft infection with Mycobacterium bovis following intravesical BCG immunotherapy diagnosed via the Karius Test™- case report and review of literature

Year: 2025

Type: article

Abstract: Bacillus Calmette-Guérin (BCG), a live attenuated form of Mycobacterium bovis, is utilized in non–muscle-invasive bladder cancer therapy. Disseminated BCG infection causing vascular graft infection is extremely rare. In this report, we review the literature and describe a rare case of aortic endograft infection in a 72- year-old man, who underwent intravesical BCG treatment four years ago that was diagnosed utilizing next generation sequencing technique via the Karius test™ enabling earlier diagnosis and treatment start compared to conventional microbiological diagnostic tools. The morbidity and mortality from aortic graft infections remain high, therefore prompt diagnosis and multidisciplinary approach is paramount.

Source: Annals of Vascular Surgery - Brief Reports and Innovations

DOI: 10.1016/j.avsurg.2025.100376

Authors: Prateek Sharma, Kristin Schafer, Richard J. Hankins, Jonathan R. Thompson, Jason R. Cook

Institution: University of Nebraska Medical Center

Language: English

Topic: Infectious Aortic and Vascular Conditions

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,490