Unique Herbal-Based Topical Is Comparable to Prescription Retinoid’s Impact on Photoaging and Repair Biomarkers
Year: 2025
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: A randomized controlled blinded pilot trial to evaluate the expression of key biomarkers of a topical cream comprising a unique blend of Herbal Extracts (HE) providing anti-inflammatory and stratum corneum repair compared to Tretinoin (Tr) 0.02% cream. Eight peri and post-menopausal women of skin types I-III with moderate to severe photodamage on forearms were evaluated. Two biomarkers for presence of photoaging revealed no statistically significant difference (p < 0.05) between HE and the prescription Tr product . These biomarkers include Fibrillin Ab and procollagen 2. Peroxisome Proliferator Activated Receptor (PPAR) gamma which is a biomarker for epidermal and stratum corneum repair was also tested. Compared to Tr, HE reached a trend toward statistical significance (p = 0.075) superiority in modulating PPAR gamma.
Authors: Thornfeldt Carl R, Smith Donna
Language: English
Topic: Skin Protection and Aging
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409070811