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Outside Front Cover: Catalyst Improved Stereoselectivity and Regioselectivity Control to Access Completely Alternating Poly(lactic‐co‐glycolic acid) with Enhanced Properties (Angew. Chem. Int. Ed. 17/2025)

Year: 2025

Type: article

Abstract: An improved stereoselective and regioselective ring-opening polymerization enables the formation of completely alternating poly(lactic-co-glycolic acid) (PLGA), as reported by Guangqiang Xu, Qinggang Wang et al. in their Communcation (e202417075). This breakthrough PLGA exhibits a record-high melting temperature (143.1°C), forms a stereocomplex (211.8°C) and demonstrates linear hydrolytic degradation with controlled drug release behavior, positioning it as an ideal carrier for long-acting therapeutic delivery.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.202506759

Authors: Xuanhua Guo, Hassan Ahmed, Guangqiang Xu, Qinggang Wang

Institutions: Chinese Academy of Sciences, Qingdao Institute of Bioenergy and Bioprocess Technology, University of Chinese Academy of Sciences

Language: English

Topic: biodegradable polymer synthesis and properties

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W4409070978

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