Pd II ‐Catalyzed γ ‐C(sp 3 )–H (Hetero)Arylation of Ketones Using Acetohydrazide As The Transient Directing Group
Year: 2025
Type: article
Abstract: Pd(II)‐catalyzed γ ‐C(sp 3 )–H (hetero)arylation of aliphatic ketones is developed using acetohydrazide as the transient directing group (TDG). The reaction is facilitated by a crucial 2‐pyridone ligand via the 5,6‐membered fused palladacycle intermediate, enabling the smooth γ ‐C(sp 3 )–H (hetero)arylation of various aliphatic ketones. The reaction demonstrated tolerance to different functional groups of aryl iodides, and compatibility with various pyridinyl or quinolinyl iodides. Furthermore, regioselectivity of γ ‐C(sp 3 )–H arylation with current reaction conditions was compared with previous studies for the challenging substrate pentan‐2‐one.
Authors: Kai Jia, Jun Luo, Chao Jiang
Institution: Nanjing University of Science and Technology
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4409075088