Year: 2025
Type: article
Abstract: A series of pyrazole -1,2,3-triazole hybrids were synthesized using a metal-free catalyst in a multicomponent reaction.The new compounds were screened for its in vitro anticancer activity against A-549 and MCF-7 cell lines.The compound featuring methyl and iodo substitutions demonstrated remarkable activity, exhibiting IC50 values of 9.25±0.2µM and 9.56±0.2µM against A-549 and MCF-7 cells, respectively.In a similar manner, the compound featuring methoxy and bromo substitutions demonstrated enhanced activity, measuring 11.42±0.2µM and 10.95±0.2µM.The compound featuring bromo and iodo substituents exhibited the highest activity, with IC50 values of 13.40±0.3µM and 12.42±0.2µM.Evaluated their toxicity on normal human embryonic kidney cells (Hek-293) and observed no morphological changes in the cells.Additionally, a molecular docking study was conducted against the proto-oncogene c-Src, revealing a highly potent ligand that demonstrated a remarkable docking score and significant binding interactions.
Source: ARKIVOC
Institution: Osmania University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4409078521