Supplemental Figure S24 from VAX014 Activates Tumor-Intrinsic STING and RIG-I to Promote the Development of Antitumor Immunity
Year: 2025
Type: supplementary-materials
Abstract: Supplemental Figure S24. STING expression is prevalent and associates with improved survival across solid tumor types. A) Percentage of patients exhibiting high STING mRNA expression levels (defined as expression value higher than the 25th percentile among all TCGA Pan-Cancer Atlas expression data) from the cBioPortal database, excluding those solid tumor indications with fewer than 100 patients. The acronyms for the individual cancer indications follow the standard TCGA study abbreviations. B) Forest plot of hazard ratios ±95% confidence intervals as determined by Cox regression analysis of progression-free survival (PFS) based on the STING expression status. C) Violin plots of RNA-Seq by Expectation Maximization (RSEM) normalized STING mRNA expression levels. Orange and blue lines represent the median and quartiles, respectively. The dashed line represents the 25th percentile of all solid tumors. D) Kaplan-Meier curves based on PFS of patients as categorized by low or high STING expression. The data sets cover all time points with a display cut-off of 120 months. †Hazard ratio is greater than 10.
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4409079266