Work

Rare Association between Minimal Change Disease and Primary Biliary Cholangitis: Case Report

Year: 2025

Type: article

Abstract: Introduction: Primary biliary cholangitis (PBC) is a chronic and progressive cholestatic liver disease that is autoimmune in nature and characterized by circulating anti-mitochondrial antibodies. A wide range of autoimmune disorders have been concomitantly observed in patients with PBC, and although quite rare PBC has been associated with a wide variety of renal disorders. Glomerular diseases have a very rare association with PBC, and these include diffuse membranous glomerulonephritis and minimal change disease, which have been sparsely described in prior literature. Presentation: Here we present a case of biopsy-proven minimal change disease in a patient with PBC treated with a course of steroids and achieving complete recovery. Conclusion: Establishing the relationship between PBC and MCD has been limited in prior literature and should be kept in mind to bring forth this rare association, which may help dictate future treatment courses.

Source: Case Reports in Nephrology and Dialysis

DOI: 10.1159/000545015

Authors: Neeraj Sharma, Heidi Duong, Bahman Moghadam, Tachaporn Sangwattanarat

Institution: University of Southern California

Language: English

Topic: Renal Diseases and Glomerulopathies

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,030