Work

DNA lesions piece together impossible trees

Year: 2025

Type: article

Abstract: DNA lesions can persist through multiple cell cycles, resulting in mutational strand asymmetry, multiallelic variation, and somatic mosaicism. But for how long do these lesions persist? Recent work from Spencer Chapman et al. shows that they can last for months to years, even arising from endogenous exposures in utero.

Source: Trends in Genetics

DOI: 10.1016/j.tig.2025.03.002

Authors: Claudia Arnedo-Pac, Sarah J. Aitken

Institutions: University of Cambridge, MRC Toxicology Unit, Medical Research Council, Yale University

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $7,030

Funders: Cancer Research UK, Medical Research Council