Work

Central lipid sensing pathways contribute to the control of puberty and its alterations in conditions of obesity

Year: 2025

Type: article

Abstract: Puberty is highly sensitive to body energy status, and child obesity is often linked to perturbed puberty. However, whether this comes from excessive energy stores or specific nutrient signals altered in obesity remains largely unexplored. Using suitable preclinical models of early obesity and accelerated puberty, we disclose herein conclusive evidence for altered hypothalamic lipid profiles and the roles of specific lipid-sensing pathways in pubertal control, with a variable contribution depending on the maturational and nutritional status.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00493.2024

Authors: Elvira Rodríguez-Vázquez, Álvaro Aranda-Torrecillas, María López-Sancho, Manuel Jiménez-Puyer, Silvia Daza-Dueñas, Alexia Barroso, Verónica Sobrino, Francisco Gaytan, Elia Obis, Juan M. Castellano, Manuel Tena-Sempere

Institutions: Instituto Maimónides de Investigación Biomédica de Córdoba, University of Córdoba, Universitat de Lleida, Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red, Hospital Universitario Reina Sofía

Language: English

Topic: Hypothalamic control of reproductive hormones

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: European Commission, Agencia Estatal de Investigación

Awards: Preventing lifetime obesity by early risk-factor identification, prognosis and intervention, G2615873709, G5356354736, G6062164702, G7113736126, G7308878917, G777485515

OpenAlex ID: W4409109190

FWCI: 2.738

Cites: 58

Cited by: 4

Related to: 10