Work

Influence of Nanoparticle Content and Cross-Linking Degree on Functional Attributes of Calcium Alginate-ZnO Nanocomposite Wound Dressings

Year: 2025

Type: article

Abstract: Alginate-ZnO nanoparticles (ZnOnano) composite wound dressing membranes were prepared with two different ZnOnano concentrations (0.03 and 0.20 g ZnO/g sodium alginate) and cross-linked with two different calcium treatments (low and high Ca++concentration) to evaluate the influence of nanoparticle content and cross-linking degree on membrane attributes. ZnOnano addition did not significantly alter the mechanical properties, water vapor permeability, swelling degree in water and the alginate amorphous nature of the nanocomposite membranes. The increase in cross-linking degree, on the other hand, altered the microstructure of the membranes, increased the tensile strength and reduced the water vapor permeability of the nanocomposite membranes. The presence of ZnOnano in alginate membranes granted them antibacterial activity in vitro against Pseudomonas aeruginosa and Staphylococcus aureus and substantially increased the absorption capacity in phosphate buffer and fetal bovine serum solutions, validating their potential use as wound dressings.

Source: Membranes

DOI: 10.3390/membranes15040108

Authors: Sergio Henrique Toledo e Silva, Andrea Cristiane Krause Bierhalz, Ângela Maria Moraes

Institutions: Universidade Estadual de Campinas (UNICAMP), Universidade Federal de Santa Catarina

Language: English

Topic: Wound Healing and Treatments

Subfield: Rehabilitation

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,654