Work

Anti-dipeptidyl-peptidase-like protein-6 (DPPX) autoimmune encephalitis associated with severe multifocal dystonia

Year: 2025

Type: article

Abstract: • Anti-DPPX encephalitis is characterized by complex symptoms, including movement disorder. • Dystonia has not been described as a phenomenon of anti-DPPX encephalitis. • Immunosuppressive therapy is the mainstay of treatment for anti-DPPX encephalitis. • Botulinum toxin administration may improve the symptoms of dystonia in anti-DPPX encephalitis. Anti-DPPX encephalitis is a rare form of autoimmune encephalitis characterized antibodies against a subunit of Kv4.2 potassium channels. Characteristic clinical features include cognitive dysfunction, parasomnias, psychosis, and seizures. Motor symptoms typically include myoclonus, tremor, and midline ataxia. DPPX encephalitis presenting as new-onset focal dystonia has not been previously described.

Source: Clinical Parkinsonism & Related Disorders

DOI: 10.1016/j.prdoa.2025.100320

Authors: Eric Roddy, Erik Gentry, Victoria Holiday, David Robertson, Peter Hedera

Institution: University of Louisville

Language: English

Topic: Autoimmune Neurological Disorders and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,730