Work

Metanephric adenoma in a pediatric patient case report

Year: 2025

Type: article

Abstract: Metanephric adenoma (MA) is a rare benign renal tumor, with an incidence of 0.2%-1%. Approximately 90% of MA cases present with the BRAF V600E mutation. This study reports an 8-year-old male child who presented with abdominal pain for one month. Abdominal ultrasound revealed a cystic necrotic mass measuring 56 × 45 mm in the right kidney. A preliminary diagnosis of Wilms tumor (WT) led to the initiation of preoperative vincristine therapy. Right nephroureterectomy was performed by pediatric surgery. Histopathological analysis could not differentiate between MA and WT. Immunohistochemical findings were positive for WT1, PANCK (weak focal), INI1 (intact), PAX8, CD56, and CD57. Genetic testing confirmed the presence of the BRAF V600E mutation (1799T > A, 1799_1800TG > AA). The patient was diagnosed with MA and was followed without chemotherapy. In conclusion, MA, which can be mistaken for WT, should be considered in the differential diagnosis of pediatric renal neoplasms. Immunohistochemical evaluation and genetic testing are essential for a definitive diagnosis.

Source: Frontiers in Pediatrics

DOI: 10.3389/fped.2025.1539220

Authors: Şule Çalışkan Kamış, Begül Yağcı, Ayşe Selcan Koç, Zeynel Abidin Taş

Institution: Sağlık Bilimleri Üniversitesi

Language: English

Topic: Renal and related cancers

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801