Work

Risk factors for hemorrhagic cystitis in children with severe beta-thalassemia after allogeneic hematopoietic stem cell transplantation

Year: 2025

Type: article

Abstract: Purpose: To investigate the risk factors for hemorrhagic cystitis (HC) in children with severe beta-thalassemia after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods: < 0.05) were included in a multivariable logistic regression model to identify independent risk factors for HC. Results: < 0.01) were independent risk factors for HC. Conclusion: Older transplantation age (>5.95 age years old), elevated pre-transplant serum ferritin levels, CMV infection, and delayed neutrophil engraftment are independent risk factors for HC in children with severe beta-thalassemia after allo-HSCT. Early identification and intervention for these risk factors are crucial in reducing the incidence of HC.

Source: Frontiers in Pediatrics

DOI: 10.3389/fped.2025.1558099

Authors: Hui-Hong Dou, Jian-Ming Luo, Yan-Jun Zhao, Ji-Gan Wang, Yuan-Han Qin

Institutions: Guangxi Medical University, First Affiliated Hospital of GuangXi Medical University, Guangxi Maternal and Child Health Hospital

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801