Year: 2025
Type: article
Abstract: Background: Basal cell carcinoma (BCC), the most common skin cancer worldwide, accounts for over 85% of non-melanoma skin cancers in Europe. A subset of patients develops multiple BCCs within a few years, termed High-Frequency BCC (HF-BCC). The most commonly used definition in recent literature of HF-BCC is 9 or more BCCs within three years. While some cases are linked to genetic syndromes like Gorlin-Goltz or xeroderma pigmentosum, non-syndromic HF-BCC remains poorly characterized. Prior studies found HF-BCC being associated with male sex, a personal history of squamous cell carcinoma, and melanoma, but further research needs to be done for risk-stratifying patients at highest risk for developing subsequent BCCs.
Source: EJC Skin Cancer
Authors: K. Wunderlich, H. Njimi, M. Suppa, V. del Marmol
Institution: Universitair Ziekenhuis Brussel
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,340
OpenAlex ID: W4409115744