Work

Patient with Gorlin Syndrome and type 2 mosaicism successfully treated with sonidegib

Year: 2025

Type: article

Abstract: Background: Nevoid basal cell carcinoma syndrome (NBCCS), or Gorlin syndrome (GS), is an autosomal dominant disorder caused by abnormalities in the sonic hedgehog signaling pathway and characterized by multiple basal cell carcinomas (BCCs) that usually develop at a young age. Treatment of the BCCs can be challenging, and Hedgehog pathway inhibitors (HPI) are a promising therapeutic strategy when surgery or other treatments are not a suitable option.

Source: EJC Skin Cancer

DOI: 10.1016/j.ejcskn.2025.100320

Authors: E. Samaniego González, M. Criado Otero, M. Navedo de las Heras, P. Bodas Gallego

Institution: Hospital Universitario de León

Language: English

Topic: Hedgehog Signaling Pathway Studies

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,340