MHC-I upregulation safeguards neoplastic T cells in the skin against NK cell-mediated eradication in mycosis fungoides
Year: 2025
Type: article
Abstract: Background: Cancer-associated immune dysfunction is a major challenge for effective therapies. The emergence of antibodies targeting tumor cell-surface antigens led to advancements in the treatment of hematopoietic malignancies, particularly blood cancers. Yet their impact is constrained against tumors of hematopoietic origin manifesting in the skin.
Source: EJC Skin Cancer
Authors: Y.-T. Chang, P. Prompsy, S. Kimeswenger, Y.-C. Tsai, D. Ignatova, O. Pavlova, C. Iselin, L. French, M. Levesque, F. Kuonen, M. Bobrowicz, P. Brunner, S. Pascolo, W. Hoetzenecker, E. Guenova
Institutions: Centre Hospitalier Universitaire Vaudois, Johannes Kepler University of Linz, University Hospital Zurich, University of Miami, Ludwig-Maximilians-Universität München, Medical University of Warsaw, Icahn School of Medicine at Mount Sinai, Universidad Complutense de Madrid, Hospital Universitario 12 De Octubre
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,340
OpenAlex ID: W4409116388