Work

Melanocytic nevi and sun exposure as major risk factors for CM. Hospital-based study in Lithuania

Year: 2025

Type: article

Abstract: the multiple cutaneous lesions, they were diagnosed as EMM.A CTguided biopsy of the lung lesions revealed metastatic melanoma with squamous proliferation.The hypopharyngeal lesions contained atypical melanocytes in the mucosal epithelium, suggesting epidermotropism.While in situ melanoma was considered a differential diagnosis, the clinical course led to the diagnosis of hypopharyngeal metastasis of EMM.Immunostaining results suggested that the interaction between CCR10 and CCL27/28 played a crucial role in the epidermotropic metastatic pattern observed in this case.Conclusions: This case suggests that EMM may exhibit epithelial tropism not only in the skin but also in mucosal tissues.

Source: EJC Skin Cancer

DOI: 10.1016/j.ejcskn.2025.100409

Authors: G. Butrimas, L. Semeklis, R. Paukstaitiene, A. Dubinskaitė, U. Janonyte, S. Valiukeviciene

Institutions: Lithuanian University of Health Sciences, Hospital of Lithuanian University of Health Sciences Kaunas Clinics

Language: English

Topic: Cutaneous Melanoma Detection and Management

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,340