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A challenging case of Pure Desmoplastic Melanoma

Year: 2025

Type: article

Abstract: Background: Desmoplastic melanoma is a rare tumor that develops preferentially on chronically sun-damaged skin of elderly patients. Its clinical appearance may be deceiving, often characterized by a slow-growing amelanotic and indurated plaque or nodule, leading to a delayed diagnosis in most cases. Histologically, it can present as two forms: 1) Pure (>90% desmoplasia), clinically more insidious and with a more sarcomatous behavior; and 2) Mixed. Overall, the survival of desmoplastic melanoma may be comparable to SSM type melanoma when matched for tumor thickness, probably due to its high tumor mutational burden.

Source: EJC Skin Cancer

DOI: 10.1016/j.ejcskn.2025.100422

Authors: A. Pagnoni, O. Pavlova, L. Tonellotto, F. Minisini, O. Marchal, E. Guenova, O. Gaide

Language: English

Topic: Cutaneous Melanoma Detection and Management

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,340

OpenAlex ID: W4409116674

FWCI:

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