Year: 2025
Type: article
Abstract: Background: Melanoma is a malignant neoplasm that is highly resistant to chemotherapy and radiotherapy and is associated with a poor prognosis in advanced stages. BRAFV600E inhibitors (BRAFi), such as Vemurafenib, reduce tumor burden, but these tumors frequently acquire resistance to these drugs. In cancer, autophagic flux acts as a survival mechanism that allows the tumor to handle with increased metabolic demand and damage caused by chemotherapeutics. Melanoma cells show constitutive activation of autophagy.
Source: EJC Skin Cancer
Authors: C. Ríos, P. Sisó, I. de la Rosa, X. Soria, X. Matias-Guiu, R.M. Martí, A. Macià
Language: English
Topic: Melanoma and MAPK Pathways
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,340
OpenAlex ID: W4409117112