Work

Epidermolysis Bullosa Acquisita as a Rare Late-Onset Immune-Related Adverse Event after Anti-PD-1-Based Immunotherapy: Case Presentation and Review of the Literature

Year: 2025

Type: article

Abstract: Background: Epidermolysis bullosa acquisita (EBA) is a rare autoimmune blistering disease caused by autoantibodies targeting type VII collagen (COL7), a component of anchoring fibrils in the basement membrane zone. These autoantibodies lead to subepidermal cleavage, resulting in skin and mucosal fragility. Although EBA has been linked to infections, autoimmune diseases, and hematologic conditions, drug-induced EBA is poorly understood.

Source: EJC Skin Cancer

DOI: 10.1016/j.ejcskn.2025.100558

Authors: E. Chatziioannou, F.C. Wolfsperger, T. Amaral

Institution: University of Tübingen

Language: English

Topic: Autoimmune Bullous Skin Diseases

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,340