Prevalence of Reported Dietary Supplement Use in 2019 Older Adult (≥ 55 Years) National Alzheimer's Coordinating Center Participants With Normal Cognition, Mild Cognitive Impairment or Dementia
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: In those with mild cognitive impairment (MCI) and dementia, nutritional intake decreases, increasing nutritional deficiency risk. Dietary supplements (DSs) may be an important source of nutrition, but recent insight into their use in those with normal cognition (NC), MCI or dementia is lacking. METHODS: A cross-sectional study design determined prevalence for reported use of 12 DS categories and 19 individual DSs based on co-participant report in 9517 older adult (≥ 55 years) National Alzheimer's Coordinating Center (NACC) participants diagnosed with NC (n = 5361), MCI (n = 1800) or dementia (n = 2347) in 2019. Multivariable binary logistic regression compared reported DS use prevalence between NC, MCI and dementia adjusting for demographics. RESULTS: Reported use of any DS was highly prevalent (NC: 76.6%, MCI: 73.9% and dementia: 69.6%). For all DS categories and many DSs, reported use was significantly lower in dementia compared to NC. Prevalence of reported use progressively declined from NC, MCI and dementia for 8/12 DS categories, including any vitamin (NC: 71.2%, MCI: 68% and dementia: 62.4%) and any mineral (NC: 34.8% MCI: 28.2% and dementia: 23.5%). This trend was also observed for 4/19 DSs, including vitamin D (NC: 49.2%, MCI: 41.2% and dementia: 36.7%). For vitamin B12 (NC: 15.5%, MCI: 18.2% and dementia: 18.5%) and melatonin (NC: 6.0%, MCI: 7.3% and dementia: 7.9%), prevalence increased from NC to MCI and from NC to dementia. CONCLUSION: For many DSs, prevalence was significantly lower in dementia compared to NC. Reported use of any DS was highly prevalent in NACC older adults with NC, MCI or dementia in 2019.
DOI: 10.1111/jhn.70049
Author: Karin E. Sandoval
Institution: Southern Illinois University Edwardsville
Language: English
Topic: Nutrition and Health Studies
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1024368718, G1048051091, G1069732457, G117713310, G120189231, G1269895679, G1458362881, G1593128567, G1753564228, G1827328465, G1859882300, G2190936067, G2234397790, G2434699210, G253265979, G2622865600, G2675915175, G2742075923, G343469054, G348743638, G3703765782, G3952091757, G415047313, G4186766937, Nevada Exploratory Alzheimer's Disease Research Center (NVEADRC), UAB Alzheimer's Disease Research Center, G504619356, G5640525220, New Mexico Alzheimer's Disease Research Center, Vanderbilt Alzheimer's Disease Research Center, G816726602, Boston University Alzheimer's Disease Research Center, Yale Alzheimer Disease Research Center, UCSD Shiley-Marcos Alzheimer's Disease Research Center P30, Joint Estimate Diffusion Imaging (JEDI) for improved Tissue Characterization and Neural Connectivity in Aging and Alzheimer's Disease, University of Kansas Alzheimer's Disease Research Center (KU ADRC), Alzheimer Disease Research Center, Alzheimer's Disease Research Center, Johns Hopkins Alzheimer's Disease Research Center, Arizona Alzheimer's Disease Research Center, Stanford Alzheimer's Disease Research Center, University of Washington Alzheimer's Disease Research Center, Wisconsin Alzheimer's Disease Research Center, Alzheimer's Disease Research Centers, University of Kentucky Alzheimer's Disease Research Center, Penn Alzheimer's Disease Research Center (ADRC), Massachusetts Alzheimer's Disease Research Center (MADRC), Goizueta Alzheimer's Disease Research Center, The Alzheimer's Disease Research Center at the University of California, Irvine
OpenAlex ID: W4409119270