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Exploring the Impact of Guselkumab and Risankizumab on Psoriasis in HIV ‐Positive Patients: Insights From Four Italian Centers

Year: 2025

Type: article

Abstract: HIV-positive patients with psoriasis often face delays in accessing biologic therapies due to their exclusion from clinical trials and concerns about the impact of immunomodulatory drugs on viral replication. Anti-IL-23 therapies, such as risankizumab and guselkumab, have shown great promise thanks to their strong efficacy and favourable safety profiles. A case series from four Italian centres reported sustained effectiveness of these drugs, with no observed effects on viral replication or immune parameters in HIV-positive patients. Although the number of cases is limited, these therapies appear to be a compelling option for patients with extensive or treatment-resistant psoriasis.

Source: Australasian Journal of Dermatology

DOI: 10.1111/ajd.14467