Work

The colorectal cancer microenvironment governs clinical behaviors and chemotherapy response

Year: 2025

Type: article

Abstract: In this study we decoded the cancer microenvironment in relation to clinical effects of chemotherapy therapies by using PDSs from primary colorectal cancers, preserving features of patient-specific heterogeneity. Important links between properties of the primary colorectal cancer microenvironment and critical clinical behaviors were revealed by detailing the protein composition of PDS and acquired resulting gene expression changes in adapting cancer cells. Scaffold proteins and induced gene changes in cancer cells were both strongly associated with the clinical response to 5-FU chemotherapy in patients, confirming encoded treatment predictive and disease specific properties within the tumor niche.

Source: Cancer Letters

DOI: 10.1016/j.canlet.2025.217687

Authors: André Holdfeldt, Simona Salerno, Anders Ståhlberg, Elinor Bexe Lindskog, Göran Landberg

Institutions: University of Gothenburg, Sahlgrenska University Hospital, Wallenberg Centre for Molecular and Translational Medicine, Region Västra Götaland

Language: English

Topic: Colorectal Cancer Treatments and Studies

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,960