Comparison of Event-based Analysis Versus Trend-based Analysis in the Detection of Glaucoma Progression by Optical Coherence Tomography 3-Dimensional Rim Measurements
Year: 2025
Type: article
Study design: Observational Study
Abstract: PRÉCIS: Compared with trend-based analysis, event-based analysis detects OCT structural progression in more patients and at an earlier time point. Using event-based analysis, MDB rim thickness detects progression more often than RNFL thickness. PURPOSE: To determine whether event-based or trend-based analysis best detects glaucoma progression using spectral domain optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) thickness and minimum distance band (MDB) neuroretinal rim measurements. METHODS: Over 5 years, 124 open angle glaucoma patients had yearly dilated eye examinations, disc photography, Humphrey visual field (HVF 24-2) testing, 2-dimensional (2D) OCT RNFL thickness measurements, and 3-dimensional (3D) OCT MDB rim measurements, all on the same day. One eye of each patient was analyzed, which was randomly selected if both eyes from a patient were eligible. Using global RNFL thickness and global MDB rim thickness, event-based progression was defined as change greater than normal aging change and expected inter-test variability. Trend-based analysis used linear regression with progression defined as rate of decline greater than age-related decline. RESULTS: The average follow-up for the 124 open angle glaucoma patients was 66.9±16.4 months. Event-based analysis was better than trend-based analysis because it detected progression in more patients (15.3% by RNFL event-based analysis versus 8.1% by RNFL trend-based analysis, P =0.025; 52.4% by MDB event-based analysis versus 9.7% by MDB trend-based analysis, P <0.001) and earlier (RNFL: mean 28.8 vs. 63.2 mo; P <0.001; MDB: mean 30.7 vs. 56.2 mo; P <0.003) whether using MDB rim thickness or RNFL thickness. Using event-based analysis, MDB rim thickness detected progression more often than RNFL thickness (52.4% vs. 15.3%; P <0.001). CONCLUSIONS: Compared with trend-based analysis, event-based analysis detected OCT structural progression in more glaucoma patients and at an earlier time point.
Source: Journal of Glaucoma
Institutions: Tufts University, Massachusetts Eye and Ear Infirmary, Harvard University, Thai Red Cross Society, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Massachusetts General Hospital, VA Boston Healthcare System, University of California, Los Angeles, University of California System, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Funders: Research to Prevent Blindness, Massachusetts General Hospital, Harvard University, American Glaucoma Society, Vrije Universiteit Amsterdam, Oogfonds, Heidelberg Engineering, National Institutes of Health, National Eye Institute, National Institute of Biomedical Imaging and Bioengineering, National Center for Research Resources, Alcon Research Institute
OpenAlex ID: W4409124845