Work

Synthesis and anti-inflammatory activity of novel 1,2,3-triazole- derivatives from 7-Oxodehydroabietic acid

Year: 2025

Type: article

Abstract: Dehydroabietic acid (DHA) is a naturally occurring diterpene with relevant biological activities. 7-Oxodehydroabietic acid as a highly oxidized state derivative from Dehydroabietic acid (DHA) showing good activities. However, the reported compounds did not include triazole derivatives. To discover novel potent anti-inflammatory diterpenoids, a series of hybrids of 7-Oxodehydroabietic acid containing 1,2,3-triazole moiety were designed and synthesized. The anti-inflammatory activity of the new compounds was assessed towards BV2 cell lines using L-NMMA (IC 50 = 42.36 ± 2.47 µ M) as a positive control. Compared with the L-NMMA, anti-inflammatory effect (NO inhibitory activities) was found in these novel molecules, especially compounds 9 (IC 50 = 8.00 ± 0.83 µ M), 10 (IC 50 = 8.44 ± 0.89 µ M), 15 (IC 50 = 8.13 ± 0.97 µ M) and 16 (IC 50 = 8.84 ± 1.10 µ M). The anti-inflammatory activity of compounds 9 , 10 , 15 and 16 in vivo are underway.

Source: BMC Chemistry

DOI: 10.1186/s13065-025-01449-7

Authors: Yong-Feng Lv, Fu-Cai Ren, Kang Hui, Jie Zheng, Shou-Jin Liu, Han Luo