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Supplementary Figure S10 from Blocking Tryptophan Catabolism Reduces Triple-Negative Breast Cancer Invasive Capacity

Year: 2025

Type: supplementary-materials

Abstract: Genetic knockdown or pharmacological inhibition of TDO2 or AhR decreased ZEB1 mRNA expression but increased while IDO1 compensated; KYN treatment increased ZEB1 expression.

DOI: 10.1158/2767-9764.28728191

Authors: Li-Wei Kuo, Lyndsey S. Crump, Kathleen O’Neill, Michelle M. Williams, Jessica L. Christenson, Nicole S. Spoelstra, Micaela Kalani Roy, Amy Argabright, Julie A. Reisz, Angelo D’Alessandro, Meher P. Boorgula, Andrew Goodspeed, Mike Bickerdike, Benjamin G. Bitler, Jennifer K. Richer

Language: English

Topic: Tryptophan and brain disorders

Subfield: Biological Psychiatry

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4409127684

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