Work

Predictive value of maternal serum placental growth factor, maternal clinical features, and fetal ultrasound indicators in preeclampsia

Year: 2025

Type: article

Abstract: OBJECTIVE: This study was aimed to evaluate the predictive value of placental growth factor (PLGF), maternal risk factors, and maternal-fetal ultrasound indicators for preeclampsia(PE) and to analyze delivery outcomes associated with PE. METHODS: Pregnant women with PE(n = 80) and healthy controls(n = 160) were enrolled from the People's Hospital of Guangxi Zhuang Autonomous Region between 2021 and 2022. Serum PLGF level were measured at various stages of pregnancy: early pregnancy, mid-pregnancy, and late pregnancy. Maternal clinical features, fetal ultrasound indicators, and pregnancy outcomes were also recorded. RESULTS: The serum concentration of PLGF was lower in the PE group compared to the control group throughout early, middle, and late pregnancy. At 20-24 weeks, the uterine artery resistance index was higher in the preeclampsia group (P < 0.05). Logistic regression analysis identified PLGF concentrations in early pregnancy and mid-pregnancy, along with mean arterial pressure (MAP), as independent factors for the onset of PE (P < 0.05). CONCLUSION: PLGF could be used for prediction of PE in early pregnancy. A predictive model for PE was established by combining the PLGF concentrations in early and middle pregnancy with MAP.

Source: BMC Pregnancy and Childbirth

DOI: 10.1186/s12884-025-07517-z