Evaluation of NHL subtypes, staging, and prognostic factors: A single-centric retrospective cohort study
Year: 2025
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: The study aims to improve the diagnosis and management of non-Hodgkin's lymphoma (NHL), identify crucial prognostic factors, expand our understanding of patients, facilitate comparative analyses, and provide clear guidance for managing NHL patients. By addressing these objectives, the study provides valuable insights into the distribution of NHL subtypes, staging workup, prognostic factors, and survival patterns in the Indian population. MATERIALS AND METHODS: This study employed a single-centric, retrospective cohort design, which was conducted from 2009 to 2014. A total of 410 participants were included with a confirmed diagnosis of NHL based on their biopsy results; the ages ranged from 4 to 91 years. Patients who missed follow-ups or did not complete the study were excluded from the survival rate analysis results. RESULTS: The gender distribution revealed that the mean ages for male and female patients were 49.37 ± 18.9 and 49.06 ± 18.34, respectively. The majority of cases in the diffuse large B cell lymphoma (DLBCL) group were under Stage 1A (47.7) and Stage 3A (23.2%). A significant portion of DLBCL cases fell into the low intermediate risk (LIR) category (27.3%). Smaller percentages are observed in the high intermediate risk (HIR) category (17.5%) and the high-risk category (9.7%). It is observed that in patients with relapse, a significant majority of cases (77.4%) were those initially diagnosed at Stage 3 or higher. 71.1% of the cases that did not have relapse had completed chemotherapy. The median survival time, according to Kaplan-Meier survival analysis, was 24 ± 1.8 months overall. CONCLUSION: While gender-based smoking and occupational disparities stand out, the prevalence of complete remission underscores treatment efficacy. Detecting challenges in advanced-stage diagnosis and incomplete treatments highlights the importance of timely intervention and comprehensive patient care. The absence of survival differences based on immunohistochemistry (IHC) subtypes suggests multifactorial influences on patient outcomes, motivating further investigation.
Authors: Ulfat A. Wani, Umeek Jeelani, Sheikh A. Aziz, Bashrat Ara Wani, Gul M. Bhat, Kaneez Fatima, Shaheen N. Lone, Asifa Andleeb
Institution: Sher-i-Kashmir Institute of Medical Sciences
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4409130263