Work

Induction and Manipulation of Biomolecular Condensates Through Spatially Heterogeneous Solution Conditions

Year: 2025

Type: article

Abstract: The study of biomolecular condensates (BMCs) is of great current interest because of the proposed roles of these types of assemblies in biological function and disease. In living cells, BMCs form in a highly heterogeneous environment and are influenced by concentration gradients of various relevant species. Furthermore, the biological functionality of the BMCs requires precise spatial control of their formation in some cases. In recent years, a number of in vitro experimental approaches have emerged that allow the generation, study, and manipulation of BMCs through the creation of well-defined spatially heterogeneous solution conditions relevant for BMC formation. In this concept article, it is presented in what way such methods can contribute to improved understanding and control of BMCs.

Source: ChemBioChem

DOI: 10.1002/cbic.202500044

Author: Alexander K. Buell

Institution: Technical University of Denmark

Language: English

Topic: RNA Research and Splicing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,430

Funder: Novo Nordisk Fonden