Work

Metabolic balance of human livers during long-term normothermic machine perfusion

Year: 2025

Type: article

Abstract: A long-term normothermic machine perfusion platform is being developed for repairing and regenerating damaged livers to make them suitable for transplantation. The energy expenditure and the metabolic needs of 14 human donor livers were observed during NMP for up to a week. We noticed that livers become metabolically quiescent after 3 days and that a change in our nutrimental support protocol might be necessary to provide a better environment for the livers during NMP.

Source: American Journal of Physiology-Gastrointestinal and Liver Physiology

DOI: 10.1152/ajpgi.00404.2024

Authors: Bianca Lascaris, Linda C. Woltjes, Silke B. Bodewes, Robert J. Porte, Vincent E. de Meijer, Maarten W. N. Nijsten

Institutions: University Medical Center Groningen, University of Groningen, Erasmus MC

Language: English

Topic: Organ Transplantation Techniques and Outcomes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Ministerie van Economische Zaken en Klimaat