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Aspergillus Spondylodiscitis in an Immunocompetent Patient With Recurrent Aspergillus Endocarditis; A Clinical Case Report

Year: 2025

Type: article

Abstract: Introduction Fungal endocarditis is a very uncommon and deadly illness that causes inflammation in the heart's lining, including the valves. Aspergillus endocarditis is the second most common cause of prosthetic endocarditis, especially the aortic valve, after Candida spp. Aspergillus endocarditis can occur on native and prosthetic valves, even in immunocompetent hosts. Case Report In this article, we describe a case of recurrent aortic-valve Aspergillus endocarditis occurring in a Caucasian man without previously known immunocompromised status with multiple brain septic emboli and spondylodiscitis. The patient was successfully responsive to liposomal amphotericin B. Discussion Early recognition in patients with underlying immunosuppressive conditions and immunocompetent hosts is critical to decreasing the mortality rate. Aspergillosis must be considered in every patient with a prior valve replacement history and culture-negative endocarditis. Surgical debridement and appropriate antifungal agents are required to resolve the problem.

Source: Open Forum Infectious Diseases

DOI: 10.1093/ofid/ofaf198