Work

Epigenetic Characterization of Squamous Cell Carcinoma and Mucoepidermoid Carcinoma Based on DNA Methylation Data: An In-Silico Study

Year: 2025

Type: article

Abstract: Background: A recent study demonstrated that parotid squamous cell carcinomas (SCCs) are most potentially metastatic cutaneous SCCs. To define whether epigenetic alterations may explain the different molecular events between SCC and Mucoepidermoid Carcinoma (MEC), this in-silico investigation analyzed DNA methylation data from open-source IDAT files on gene ontology corresponding to 156 surgical resections of gingivobuccal SCC, parotid/skin SCC and salivary MEC.

Source: EJC Skin Cancer

DOI: 10.1016/j.ejcskn.2025.100695

Authors: B.K. Othman, A. Skalova

Institutions: Charles University, Biopticka Laborator (Czechia)

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,340