Work

Age-related differences in atypical Spitz tumours: characterisation and management strategies in a single centre cohort

Year: 2025

Type: article

Abstract: Background: Atypical Spitz tumours (AST) are rare melanocytic lesions with overlapping features of benign Spitz nevi and spitzoid melanoma, making their diagnosis and management challenging. These tumours often exhibit histopathological and molecular variability, which further complicates their differentiation from malignant counterparts. Paediatric patients tend to present with distinct clinical and histological patterns, including thicker lesions and unique molecular features. Despite advances in diagnostic techniques, there is no standardised approach to the management of AST and sentinel lymph node biopsy (SLNB) remains controversial.

Source: EJC Skin Cancer

DOI: 10.1016/j.ejcskn.2025.100674

Authors: F. Cassalia, P. Del Fiore, E. Guadagnini, M. Mazza, S. Mocellin, A. Belloni Fortina

Institutions: University of Padua, Istituto Oncologico Veneto

Language: English

Topic: Cutaneous Melanoma Detection and Management

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,340