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Adjuvant Radiotherapy for Melanoma – The End of an Era? A Study of the Management of Resectable Melanoma Following Approval of Adjuvant Systemic Therapies

Year: 2025

Type: article

Abstract: Background: Historically, adjuvant radiotherapy has been utilised for resected node positive melanoma in the presence of high-risk features including extracapsular extension and large nodal deposits. Radiotherapy to the nodal basin compared with observation significantly reduces the risk of nodal relapse (HR 0.52, 95% CI 0.31-0.88 p=0.023), however, a benefit in overall or recurrence-free survival has not been shown[1]. With the recent introduction of adjuvant systemic treatments, the use of adjuvant radiotherapy has declined significantly.

Source: EJC Skin Cancer

DOI: 10.1016/j.ejcskn.2025.100578

Authors: L. Stockton, S. Abdoun, K. Fife, B. O'Carrigan

Institution: Cambridge University Hospitals NHS Foundation Trust

Language: English

Topic: Cutaneous Melanoma Detection and Management

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,340