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A Case of Unusual Umbilical Lichen Planus Associated with Pembrolizumab

Year: 2025

Type: article

Abstract: Background: A 65-year-old white Caucasian man developed violaceous, scaly, pruritic plaques on the umbilicus and lower back 12 weeks into adjuvant pembrolizumab therapy following nephrectomy for high-risk clear cell renal carcinoma. Initially thought to be psoriasis due to possible Koebnerization on old scars, the rash expanded to involve the palms, thighs, buttocks, groin, and penis. Diagnostic biopsies performed after dermatology review revealed hyperkeratosis, acanthosis with elongated rete ridges, vacuolar interface dermatitis, Civatte bodies, and a band-like lichenoid inflammatory infiltrate consistent with lichen planus.

Source: EJC Skin Cancer

DOI: 10.1016/j.ejcskn.2025.100540

Authors: T. Foord, E. Kolson Kokohaare, J. Oldham, A. Rullan, N. Mansoor

Institution: The Royal Free Hospital

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,340