Work

Multicentre Prospective Study on Mucosal Associated Invariant T Cells in Patients with Melanoma

Year: 2025

Type: article

Abstract: Background: Skin cancer is the most common group of cancers worldwide. Melanoma accounts for 1 in 5 skin cancers with projections to increase by 50% by 2040. The introduction of immunotherapy in the last decade has greatly improved outcomes, notably PD-1 check point inhibitors. Not all patients who receive immunotherapy derive long term benefit, this indicates the need for better biomarkers to guide targeted treatment. Much research concerning factors associated with responses to immune checkpoint inhibitors focussed on the contributions of conventional peptide-specific T cells, the role of unconventional T cells, such as mucosal-associated invariant T (MAIT) cells, remains largely unknown.

Source: EJC Skin Cancer

DOI: 10.1016/j.ejcskn.2025.100515

Authors: S. O’Mahony, A. Berisha, A. Hogan, A.M. Tobin

Institutions: Trinity College Dublin, Tallaght University Hospital, National University of Ireland, Maynooth

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,340