Year: 2025
Type: article
Study design: Observational Study
Abstract: Loneliness is a neuropsychiatric symptom that has been associated with cognitive impairment and dementia. We aimed to investigate whether depressive symptomatology and biomarkers of Alzheimer's disease (AD) and cerebrovascular disease (CVD) are associated with loneliness. Secondly, we aimed to investigate whether loneliness, depressive symptomatology, and biomarkers of AD and CVD are associated with subjective cognitive decline (SCD). We included 215 cognitively unimpaired participants (70 y/o) with cerebrospinal fluid biomarkers, magnetic resonance imaging, and questionnaires for loneliness, depressive symptomatology, and SCD. For aim 1, our findings showed that CVD and depressive symptomatology were the most relevant measures to discriminate people with loneliness. For aim 2, a random forest classification model showed that loneliness contributed to discriminate individuals with SCD, but logistic regression showed that its partial predictive effect was non-significant when depressive symptomatology and AD biomarkers were included in the models. We conclude that loneliness is associated with SCD, CVD, and depressive symptomatology. Given the complex interplay between loneliness, depressive symptomatology, and SCD, more research is needed to fully clarify the unique role of each neuropsychiatric symptom in relation to biomarkers of brain pathology.
Source: Scientific Reports
Institutions: Universitat de València, Karolinska Institutet, Stockholm University, Universidad Fernando Pessoa Canarias, University of Gothenburg, Sahlgrenska University Hospital, Region Västra Götaland, Universidad de Zaragoza, Instituto de Investigación Sanitaria Aragón, Centro de Investigación Biomédica en Red de Salud Mental, King's College London
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
Funders: Alzheimer's Association, Alzheimer's Drug Discovery Foundation, Familjen Erling-Perssons Stiftelse, Gun och Bertil Stohnes Stiftelse, Stiftelsen för Gamla Tjänarinnor, EU Joint Programme – Neurodegenerative Disease Research, Ministerio de Ciencia, Innovación y Universidades, European Commission, Stiftelsen för Strategisk Forskning, Generalitat Valenciana, Hjärnfonden, Karolinska Institutet, Vetenskapsrådet, Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse, Forskningsrådet om Hälsa, Arbetsliv och Välfärd, Alzheimerfonden, Gobierno de Aragón, UK Dementia Research Institute, Demensfonden, National Institutes of Health, Agencia Estatal de Investigación, Center for Innovative Medicine, European Social Fund, H2020 European Research Council, NextGenerationEU
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OpenAlex ID: W4409147558