Augmented renal clearance in neurocritical patients: An epidemiological investigation and risk-factor analysis.
Year: 2024
Type: article
Study design: Observational Study
Abstract: OBJECTIVES: Augmented renal clearance (ARC), in contrast to renal dysfunction, refers to enhanced renal elimination of circulating solutes compared to the expected baseline. Although patients may present with normal serum creatinine (Scr) levels, the incidence of ARC is high in intensive care unit (ICU) settings. ARC is associated with subtherapeutic exposure and treatment failure of renally cleared antibiotics. However, limited research exists on the incidence and risk factors of ARC in the ICU, and even fewer data are available specifically for neurological ICU (NICU). This study aims to determine the incidence and risk factors of ARC in neurocritically ill patients. METHODS: <0.05 in univariate analysis were included in binary Logistic regression to identify independent risk factors for ARC. RESULTS: 2.568 to 15.310) were significant predictors of ARC. CONCLUSIONS: ARC is relatively common in the NICU. A considerable number of patients with initially normal renal function developed ARC during hospitalization. Younger age and concurrent severe bacterial infection are important risk factors of ARC in neurocritically ill patients.
Source: PubMed
Authors: Qile Xiao, Bohan Luo, Hainan Zhang, Xiaomei Wu
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4409147583