Year: 2025
Type: article
Study design: Observational Study
Abstract: PD patients present with diverse symptoms, complicating timely diagnosis. We analyzed 1124 PD trajectories using a novel model-based approach to estimate whether diagnosis was early or late compared to cohort averages. Higher age, specific non-motor symptoms, and fast disease progression were linked to later diagnosis, while gait impairment led to earlier diagnosis. Our findings are in line with a biological definition of PD that extends beyond classical motor symptoms.
Source: npj Parkinson s Disease
Institutions: Fraunhofer Institute for Algorithms and Scientific Computing, University Hospital Carl Gustav Carus, Technische Universität Dresden, University of Bonn, Bonn Aachen International Center for Information Technology, Centre Hospitalier de Luxembourg, University of Luxembourg, Luxembourg Institute of Health, Luxembourg Centre for Systems Biomedicine, Centre National de la Recherche Scientifique, Inserm, Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Institut du Cerveau, German Center for Neurodegenerative Diseases (DZNE) Dresden
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,890
OpenAlex ID: W4409147670