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Assessing the safety and efficacy of an anaesthetic protocol combining tiletamine, zolazepam and xylazine when used in tigers

Year: 2025

Type: article

Abstract: Background Due to the limited availability of ketamine in Mexico, alternative anaesthetic protocols for the immobilisation of big cats such as tigers (Panthera tigris ssp.) need to be considered. Therefore, this study aimed to assess the safety and efficacy of an anaesthetic protocol combining tiletamine, zolazepam and xylazine when used in tigers. Methods Sixteen tigers (seven P. tigris tigris and nine P. tigris altaica) at two zoological institutions in Mexico were included in the study. Tigers were either darted or hand injected with a combination of tiletamine/zolazepam (1.5 mg/kg) and xylazine (0.5 mg/kg). Physiological variables, including heart rate (HR), respiratory rate (RR), body temperature, arterial haemoglobin oxygen saturation (SpO2), systolic blood pressure (SAP), diastolic blood pressure (DAP) and mean arterial pressure, were measured and recorded. The tigers were divided into two groups according to their weight: light (≤40 kg) and heavy (≥100 kg). Wilcoxon rank tests were then used to assess the effects of anaesthesia on HR, RR, SpO2, SAP and DAP. Results HR and weight varied significantly among the tigers included in the study, but no statistically significant differences in RR, body temperature, SpO2, SAP or DAP were found. Time to recovery was shorter in tigers that received atipamezole than in those that did not. Limitations The weight, age and sex group sample sizes were unequal. As such, caution should be employed when attempting to draw conclusions from these group comparisons. Conclusion Despite the controversy associated with tiletamine/zolazepam use in tigers, no adverse effects were observed. Therefore, a combination of tiletamine, zolazepam and xylazine is a suitable alternative for tiger anaesthesia when ketamine is not available.

Source: Veterinary Record

DOI: 10.1002/vetr.5228

Authors: Julio A. Mercado, Horacio de la Cueva, Thomas G. Curro, Alejandro Román, Paulina Haro

Institutions: Universidad Autónoma de Baja California, Centro de Investigación Científica y de Educación Superior de Ensenada, Instituto Tecnológico de Tehuacán

Language: English

Topic: Veterinary Pharmacology and Anesthesia

Subfield: Small Animals

Field: Veterinary

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4409148030

FWCI:

Cites: 13

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Related to: 10