Type 1 diabetes mellitus increases the risk of sudden sensorineural hearing loss: A two-sample Mendelian randomization study.
Year: 2024
Type: article
Study design: Observational Study
Abstract: OBJECTIVES: Diabetes mellitus is closely associated with sudden sensorineural hearing loss (SSNHL), but no definitive evidence has established a causal relationship between type 1 diabetes mellitus (T1DM) and SSNHL. This study aims to investigate the impact of T1DM on SSNHL from a genetic perspective, providing insights for risk prediction and treatment strategies. METHODS: test was applied to evaluate the heterogeneity of the selected instrumental variables, MR-PRESSO was applied to detect outliers, MR-Egger regression was used to assess horizontal pleiotropy and leave-one-out analysis was conducted to examine the robustness of individual single nucleotide polymorphisms (SNPs) on the overall results. RESULTS: =0.356). Leave-one-out analysis confirmed the robustness of the findings, as the results remained stable after removing individual SNPs. CONCLUSIONS: Two-sample MR analysis supports the conclusion that T1DM patients have an increased risk of developing SSNHL.
Source: PubMed
Authors: Yan Ding, Kangjia Zhang, Yong Zhang, Weijing Wu, Zi'an Xiao, Ruosha Lai
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4409148103