Work

Premetastatic niche mechanics and organotropism in breast cancer

Year: 2025

Type: review

Abstract: Numerous physical and mechanical changes occur in the premetastatic niche. Here, we review the mechanics of the premetastatic niche and how the altered extracellular matrix and cancer cell mechanics may play a role in organotropism in breast cancer. Future research into premetastatic niche development and organotropic cell behavior should address physical alterations and biomechanical effects to the same rigor that biochemical alterations are studied.

Source: npj Biological Physics and Mechanics.

DOI: 10.1038/s44341-025-00015-5

Authors: Sarah Libring, Cynthia A. Reinhart-King

Institution: Rice University

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,490