Work

A Cascade Cyclization of Orthogonally Protected Diaminodiazoketones to Sp3‐Enriched Fused 1,2,3‐Triazoles

Year: 2025

Type: article

Abstract: A convenient approach to the synthesis of sp3‐enriched bicyclic 1,2,3‐triazole derivatives based on the cascade cyclization of diaminodiazoketones with orthogonal protecting groups has been developed. The method is based on available commercial starting compounds and simple, environmentally acceptable synthesis methods. The formation of a condensed 1,2,3‐triazole ring is accompanied by the loss of chirality of the carbon atom near Boc‐amino group.

Source: ChemistrySelect

DOI: 10.1002/slct.202406027

Authors: Oleg Svaljavin, V'iacheslav Pendyukh, Hanna Yakovleva, Svetlana Shishkina, Dmitriy Volochnyuk, Serhii Bohza

Institutions: Institute of Organic Chemistry, State Scientific Institution “Institute for Single Crystals” of National Academy of Sciences of Ukraine

Language: English

Topic: Cyclopropane Reaction Mechanisms

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: National Academy of Sciences of Ukraine

Award: G5611982881