Work

Spontaneous alternation of place-cell sequences in the open field through spike frequency adaptation

Year: 2025

Type: article

Abstract: Spatial sequences encoded by cells in the hippocampal-entorhinal region have been observed to spontaneously alternate across the animal's midline during navigation in the open field, but it is unknown how this occurs. We show that sinusoidal sampling patterns emerge rapidly and robustly in a simple model of the hippocampal place-cell sequences based on spike frequency adaptation that makes no assumptions about sequence direction. We corroborate our findings using hippocampal data from rats performing a spatial memory task in the open field.

Source: Cell Reports

DOI: 10.1016/j.celrep.2025.115475

Authors: John Widloski, David Theurel, David J. Foster

Institution: University of California, Berkeley

Language: English

Topic: Memory and Neural Mechanisms

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $5,620

Funder: National Institutes of Health