Differential expression of eicosanoid pathways after whole blood stimulation in asthma patients
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objectives: Asthma is a heterogeneous disease regarding its pathophysiology, clinical symptoms, and response to treatment. Eicosanoids are important inflammatory mediators, able to either promote or attenuate the underlying chronic airway inflammation. We compared eicosanoid expression patterns in the blood circulation and in stimulated blood leukocytes of asthma patients to identify differences in eicosanoid release which may be related to airway inflammation. Methods: ). Results: in steroid-naïve asthmatics with moderate as well as severe disease severity but not in subjects with systemic steroid treatment. Furthermore 15-Hydorxyeicosatetraenoic acid (15-HETE) production was elevated in asthmatic patients with mild-to-moderate disease activity but dropped down in severe asthmatics. Conclusions: Profiling of eicosanoid production in stimulated whole blood samples showed a specific biosynthesis pattern of asthmatic patients, which is influenced by the use of systemic corticosteroids.
Authors: Chrysanthi Skevaki, Pavel Tafo, Thomas Bahmer, Mustafa Abdo, Henrik Watz, Frauke Pedersen, Christian Herzmann, Klaus F. Rabe, Harald Renz, Wolfgang Andreas Nockher, Mira Bürk, Markus Ege, Alexander Hose, Sabina Illi, Constanze Jakwerth, Kristina Laubhahn, Lena Lagally, Nicole Maison, Jimmy Omony, Bianca Schaub, Carsten Schmidt-Weber, Lena Ullemeyer, Erika von Mutius, Esther Zeitlmann, Ulrich Zissler, Mustafa Abdo, Thomas Bahmer, Heike Biller, Xenia Bovermann, Folke Brinkmann, Karoline I. Gaede, Christian Herzmann, Clara Haug, Berrit Liselotte Husstedt, Nikolas Jacobs, Anne-Marie Kirsten, Inke R. König, Matthias V. Kopp, Gyde Nissen, Catharina Nitsche, Frauke Pedersen, Klaus F. Rabe, Isabell Ricklefs, Alena Steinmetz, Lea Kronziel, Vera Veith, Gesche Voigt, Henrik Watz, Markus Weckmann, Mifflin-Rae Calvero, David S. DeLuca, Anna-Maria Dittrich, Christian Dopfer, Svenja Gaedcke, Ruth Grychtol, Anika Habener, Gesine Hansen, Christine Happle, Adan Chari Jirmo, Bin Liu, Lennart Riemann, Nicolaus Schwerk, Svenja Foth, Harald Renz, Christin Langer, Stefanie Weber, Miguel A. Alejandre Alcazar, Samira Blau, Silke van Koningsbruggen-Rietschel, Ernst Rietschel, Tobias Trojan
Institutions: Philipps University of Marburg, Justus-Liebig-Universität Gießen, German Center for Lung Research, Universities of Giessen and Marburg Lung Center, University Hospital Schleswig-Holstein, LungenClinic Grosshansdorf, Research Center Borstel - Leibniz Lung Center, Ludwig-Maximilians-Universität München, Helmholtz Munich, Technical University of Munich, University of Lübeck, University of Bern, University Hospital of Bern, University Children’s Hospital Bern, Medizinische Hochschule Hannover, Universitätsklinikum Gießen und Marburg, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University Hospital Cologne
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,508
Funders: Philipps-Universität Marburg, Thermo Fisher Scientific, Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung und Forschung, Stiftung für Pathobiochemie und Molekulare Diagnostik, Uniklinikum Giessen und Marburg, Deutsches Zentrum für Lungenforschung, Universities of Giessen and Marburg Lung Center
Awards: KFO 309: Virusinduced Lung Injury:
Pathobiology and Novel Therapeutic Strategies, G4041816930, G5546591189, G5802545276, SFB 1021: RNAViren: Metabolismus viraler RNA, Immunantwort der Wirtszellen und virale Pathogenese, Die Entwicklung des AntikörperRepertoires gegen Rhinoviren und Hausstaubmilben in Relation zu Krankheitsbeginn und –persistenz des Asthma bronchiale: Eine hochauflösende Analyse bei Menschen und Mäusen, G7462000889
OpenAlex ID: W4409154532