Work

Prior guided deep difference meta-learner for fast adaptation to stylized segmentation

Year: 2025

Type: article

Abstract: Radiotherapy treatment planning requires segmenting anatomical structures in various styles, influenced by guidelines, protocols, preferences, or dose planning needs. Deep learning-based auto-segmentation models, trained on anatomical definitions, may not match local clinicians’ styles at new institutions. Adapting these models can be challenging without sufficient resources. We hypothesize that consistent differences between segmentation styles and anatomical definitions can be learned from initial patients and applied to pre-trained models for more precise segmentation. We propose a Prior-guided deep difference meta-learner (DDL) to learn and adapt these differences. We collected data from 440 patients for model development and 30 for testing. The dataset includes contours of the prostate clinical target volume (CTV), parotid, and rectum. We developed a deep learning framework that segments new images with a matching style using example styles as a prior, without model retraining. The pre-trained segmentation models were adapted to three different clinician styles for post-operative CTV for prostate, parotid gland, and rectum segmentation. We tested the model’s ability to learn unseen styles and compared its performance with transfer learning, using varying amounts of prior patient style data (0–10 patients). Performance was quantitatively evaluated using dice similarity coefficient (DSC) and Hausdorff distance. With exposure to only three patients for the model, the average DSC (%) improved from 78.6, 71.9, 63.0, 69.6, 52.2 and 46.3–84.4, 77.8, 73.0, 77.8, 70.5, 68.1, for CTV style1 , CTV style2 , CTV style3 , Parotid superficial , Rectum superior , and Rectum posterior , respectively. The proposed Prior-guided DDL is a fast and effortless network for adapting a structure to new styles. The improved segmentation accuracy may result in reduced contour editing time, providing a more efficient and streamlined clinical workflow.

Source: Machine Learning Science and Technology

DOI: 10.1088/2632-2153/adc970

Authors: Dan Nguyen, Anjali Balagopal, Ti Bai, Michael Dohopolski, Mu-Han Lin, Steve Jiang

Institution: The University of Texas Southwestern Medical Center

Language: English

Topic: Medical Image Segmentation Techniques

Subfield: Computer Vision and Pattern Recognition

Field: Computer Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,000