Work

Transition-metal-free regioselective synthesis of spiro-oxazolidines through [3 + 2] annulation reactions of azadienes with haloalcohols

Year: 2025

Type: article

Abstract: The transition-metal-free regioselective [3 + 2] annulation of azadienes with haloalcohols for the preparation of highly functionalized spiro-oxazolidines is experimentally simple and proceeds under mild conditions. The metal-free protocols have more significance than the metal-catalyzed ones when the toxicity associated with the metal catalyst is considered. This transformation features a broad substrate scope, good yields, and excellent regioselectivity. Moreover, large-scale synthesis and representative transformations of spiro-oxazolidines were carried out to provide additional evidence on the practicality of this approach.

Source: RSC Advances

DOI: 10.1039/d5ra01423a

Authors: Amol T. Savekar, Sonali M. Vitnor, Vishal B. Karande, Suresh B. Waghmode

Institution: Savitribai Phule Pune University

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,042

Funders: University Grants Commission, Savitribai Phule Pune University, Science and Engineering Research Board