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Hyperoxia-induced senescence in fetal airway smooth muscle cells: role of mitochondrial reactive oxygen species and endoplasmic reticulum stress

Year: 2025
Type: article
Abstract: (hyperoxia) in premature infants detrimentally affects bronchial airways leading to increased senescence. Understanding the mechanisms by which hyperoxia initiates senescence in developing airways is critical for future therapeutic strategies. The current study showed that hyperoxia-induced senescence is mediated through increased mitochondrial reactive oxygen species and endoplasmic reticulum (ER) stress. ER stress inhibitors or mitochondria-targeted antioxidants may represent future therapies to blunt detrimental effects of supplemental oxygen in developing lungs.
DOI: 10.1152/ajplung.00348.2024
Authors: Maunick L. Koloko Ngassie, Michael A. Thompson, Benjamin B. Roos, Savita Ayyalasomayajula, Antony B. Lagnado, João F. Passos, Christina M. Pabelick, Y. S. Prakash
Institution: Mayo Clinic
Language: English
Field: Medicine
Open Access status: green
Awards: G3273312473, G355826704, G4590050280, G6598503, The role of sub-lethal mitochondrial apoptotic stress in cellular senescence, Cellular Senescence in Neonatal Airways, Neonatal Modulation of Airway Contractility, Cellular Senescence in Trisomy 21 lung disease
OpenAlex ID: W4409162254
FWCI: 5.296
Cites: 94
Cited by: 9
Related to: 10